Another quarterback injury has changed the perception of the Arizona Cardinals again, at least in the betting line. The Cardinals are the biggest underdogs ever for an 11-3 team, going back to when it was first tracked in 1980, according to OddsShark.com . Arizona is an eight-point underdog to the Seattle Seahawks, according to Yahoo Pro Football Pick 'em lines. They're a huge underdog even though they're at home. There haven't been too many teams that have been exactly 11-3, and even fewer that have been underdogs at all, so the sample size isn't tremendous, but the line is telling. [ Join FanDuel.com's $2M Week 16 fantasy league: $25 to enter; top 17,475 teams paid ] Nobody expects the Cardinals to win with third-string quarterback Ryan Lindley against a Seahawks' pass defense that has been stifling the past few weeks. Never put anything past the Cardinals, who have overcome numerous injuries to already clinch a playoff berth, but this task seems to be a bit much. And with a win, the Seahawks would pull even with the Cardinals and clinch the tiebreaker, so they’d have the inside track for the NFC West title. All these injuries are not really fair for the Cardinals. No team is fully healthy this time of the NFL season, but the Cardinals’ plight has been tougher than most. That won’t matter to the Seahawks, who are trying to repeat as Super Bowl champions. And I can’t pick Lindley and the Cardinals either. If Bruce Arians can muster enough points with a quarterback who has a 46.8 career rating to beat the Seahawks, he’s an even better coach that we realize. It’s unfortunate for the Cardinals that they have to play such a big game so shorthanded, but the NFL isn’t always fair. Here are the rest of the Week 16 picks: Jaguars (-3.5) over Titans ( picked Thursday ): Moving on. Redskins (+7.5) over Eagles: Seems like a letdown spot after such a big game for Philadelphia last week, though the Eagles might be focused coming off a loss. Either way, it’s nice to have Saturday NFL football back. 49ers (-1) over Chargers: The Chargers’ offensive explosion at Baltimore seems to be an outlier. It doesn’t surprise me at all to hear that Philip Rivers is dealing with injuries. He doesn’t look right lately and neither does San Diego.
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